ELECTROSPUN NANOFIBERS FOR IMPROVED CELL ADHESION
Research has shown that nano-topographical shapes can influence cellular attachment, proliferation, morphological, endocytotic activity, and gene expressions of various cell types. Electrospinning is a convenient and effective method for producing continuous nanofibres from most polymers, allowing us to rapidly survey the effect of their chemical and physical aspects on controlling the growth of mammalian cells.
Electrospun nanofibres have increased surface-area-to-volume ratios, flexible morphological designability, and a structure strikingly similar to extracellular matrix; makes it an ideal scaffold for tissue engineering.
These scaffolds may also be used to increase the extracellular vesicle release from cells and to use them as bio-camouflaged drug delivery vehicles.
Thomas Nann Research group
University of Newcastle, Australia
Victoria University of Wellington, New Zealand